• Partner with scientists in discovery and development functions to
guide and facilitate decision-making process in early drug development• Provide scientific leadership in early drug development arena
• Assure science- and data-based approaches to critical questions
-Basic sciences, preclinical sciences (toxicology/ ADME/ CMC), early clinical medicine
• Avoid unnecessary studies at wrong time• Define critical questions for research efforts and guide robust
experimental approach to these questions
• Definition of creative, robust approaches to resolution of difficult preclinical toxicology/
ADME questions
• Development of creative, robust approaches to rapid demonstration of POC/POA in patients